Sirena grew up around the U.S. and abroad her mother, Margaret Irwin-Brandon, is a harpsichordist and conductor of a Baroque Orchestra, and her father, John Irwin, was a physicist (with a significant stint as a dropped out hippie)-landed ultimately at Sanford University. After time spent at Northfield Mt. Hermon boarding school where she fell in love with theater, she attended San Francisco State University and graduated with degrees in Theater and International Relations. After a successful stint in a popular San Francisco sketch comedy group, she landed in Los Angeles where her knack for voices and accents were quickly put to use in the world of animation. This ultimately brought her to her successful career as a voice director in animation (thanks to her mentor Andrea Romano!) garnering her an Emmy nomination in 2021.